N-acetylcysteine inhibits alveolar epithelial-mesenchymal transition

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N-acetylcysteine inhibits alveolar epithelial-mesenchymal transition.

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BACKGROUND Idiopathic pulmonary fibrosis (IPF) is a progressive and lethal lung disease characterized by the accumulation of excessive fibroblasts and myofibroblasts in the extracellular matrix. The transforming growth factor β1 (TGF-β1)-induced epithelial-to-mesenchymal transition (EMT) is thought to be a possible source of fibroblasts/myofibroblasts in IPF lungs. We have previously reported t...

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ژورنال

عنوان ژورنال: American Journal of Physiology-Lung Cellular and Molecular Physiology

سال: 2009

ISSN: 1040-0605,1522-1504

DOI: 10.1152/ajplung.00009.2009